Intradermal versus Subcutaneous Immunization of Monkeys against Poliomyelitis

Intradermal Immunization of Monkeys with One Set of Injections of Poliomyelitis Virus

1. By means of a single large dose of poliomyelitis virus, distributed at a number of intradermal sites, active immunity has been produced in Macacus rhesus monkeys, as shown by skin neutralization and intracisternal tests. 2. In the small series (four animals) of monkeys so treated, neither abortive nor paralytic signs of experimental poliomyelitis appeared.

The expanded programme in immunization against measles and poliomyelitis, Iran's Experience.

Experiments on Active Immunization against Experimental Poliomyelitis

The results obtained in this investigation indicate that poliomyelitis virus treated with tannin, sodium ricinoleate, or formalin does not constitute a satisfactory immunizing agent in monkeys against the experimental disease.

Experiments with the Virus of Poliomyelitis

1. Efforts to adapt the virus of poliomyelitis to the rabbit organism and to produce poliomyelitis in rabbits by testicular injection and by brain injection after testicular passage produced no evidence that the virus could be adapted in this manner. Suggestive symptoms produced in very young rabbits were duplicated in non-specifically treated and in uninoculated controls. The admixture of a va...

Mycobacterium bovis BCG induces similar immune responses and protection by rectal and parenteral immunization routes.

We compared cellular immune responses to rectal, subcutaneous, and intradermal administration of Mycobacterium bovis BCG for 5 to 20 weeks in mice, guinea pigs, and macaques. Strong lymphoproliferative responses were induced in spleen cells after in vitro stimulation with purified protein derivative in guinea pigs and macaques, whatever the route of immunization. Comparable high numbers of gamm...